Endothelial dysfunction in arterial hypertension

Evidence of dysfunction of endothelial progenitors in pulmonary arterial hypertension.

RATIONALE Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain. Endogenous endothelial progenitor cells are potential contributors to this process. OBJECTIVES To determine whether progenitors are involved in the pat...

Peripheral endothelial dysfunction in patients with pulmonary arterial hypertension.

BACKGROUND Pulmonary endothelium plays an important role in the mechanism of pulmonary arterial hypertension (PAH). However, there is only a few data regarding the systemic endothelium in this syndrome. This study focused on the systemic endothelial involvement in PAH. METHODS Endothelial function was evaluated in 54 patients with idiopathic (n=28), scleroderma-associated (n=10), chronic thro...

Erectile dysfunction in arterial hypertension

Funding / potential competing interests: No financial support and no other potential conflict of interest relevant to this article were reported. Correspondence: Thomas Dieterle; MD Divisional Medical and Scientific Affairs, Roche Diagnostics, Basel, and Department of Internal Medicine, University Hospital Basel Grenzacherstrasse CH – 4070 Basel thomas.dieterle[at]usb.ch; thomas.dieterle[at]roc...

Endothelial dysfunction and hypertension.

Endothelial dysfunction in pulmonary hypertension.

The pathogenesis of pulmonary hypertension (PH) involves a complex and multifactorial process. Endothelial dysfunction seems to play an integral role in mediating the structural changes in the pulmonary vasculature. Disordered endothelial cell proliferation along with concurrent neoangiogenesis, when exuberant, results in the formation of glomeruloid structures known as the plexiform lesions, w...